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Also, the established diagnostic indicators present in AD are seen in other forms of dementia including frontotemporal, vascular, diffuse Lewy body, corticobasal, dementia due to Parkinson’s disease, type 2 diabetes, and HIV infection, as well as normal aging [31]

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While several senolytic and senomorphic therapies show promise in clearing senescent cells and impacting age-related conditions, many lack data on CNS penetrance and efficacy in AD relevant systems