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Moreover, supplementation with Lactobacillus plantarum (DP189) and GOS restored gut microbial composition, improved gut and BBB integrity, reduced cortical inflammation and elevated acetylcholinesterase activity, reversing anxiety and depression-like behaviors in mice (Wang J
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Interestingly, the overexpression of CB 1 Rs in adult mice undergoing experimental demyelination resulted in delayed onset and reduced severity of symptoms, whereas CB 1 R antagonism quickened symptom onset and increased the expression of inflammatory cytokines and NF-κB proteins (Lou et al., 2016, 2018)
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